Antigenic variation among murine coronaviruses: Evidence for polymorphism on the peplomer glycoprotein, E2
نویسندگان
چکیده
منابع مشابه
Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence.
Strains of the murine coronavirus mouse hepatitis virus type 4 (MHV-4) which contained a mutation in the E2 peplomer glycoprotein were obtained by selection for resistance to neutralization by monoclonal antibodies. Characterization of six variants representing two independent epitopes on E2, E2B and E2C, by in vitro neutralization and antibody-binding assays demonstrated that selection for an ...
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Antigenic and genomic relationships among tissue culture-adapted turkey enteric coronavirus (TCV) isolates, three strains of avian infectious bronchitis virus (IBV), and mammalian coronaviruses were investigated. Immunoblotting and immunoprecipitation experiments using polyclonal antisera showed that the four major structural proteins of TCV cross-reacted with the four homologous proteins of bo...
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The feline coronaviruses can be divided into two distinct antigenic groups on the basis of antigenic differences found on the peplomer (E2) glycoprotein of the virus. Because the E2 glycoprotein is responsible for many of the biological functions of coronaviruses, experiments were done to determine whether there were any E2 functional differences between these two antigenic groups. The avirulen...
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Recent reports relative to the oncogenicity of adenovirus types 12 and 18 (Trentin, Yabe, and Taylor, Science 137:835, 1962; Huebner, Rowe, and Lane, Proc. Natl. Acad. Sci. U.S. 48:2051, 1962) have caused a renewed surge of interest in the adenovirus group. In addition to the prototype strain Huie, Huebner and co-workers investigated eight adenovirus type 12 strains, recovered from anal swabs o...
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Four antigenic sites of the E2 glycoprotein of transmissible gastroenteritis virus were defined by competitive radioimmunoassays of monoclonal antibodies (MAbs). Here, we describe the localization of these sites by testing the antigenicity of protein fragments and prokaryotic expression products of E2 gene fragments, and by sequencing of MAb-resistant (mar) mutants. Partial proteolysis of purif...
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ژورنال
عنوان ژورنال: Virus Research
سال: 1985
ISSN: 0168-1702
DOI: 10.1016/0168-1702(85)90028-0